This episode features a Q&A session with Dr. Rhonda Patrick. The questions were sourced from social media followers of both FoundMyFitness and also Zero Fasting Tracker, a convenient mobile app used widely in the fasting community for logging. In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including: What effects coffee, supplements, and amino acids have on fasting Whether one method of fasting is more beneficial than others What effect the...more
Dale E. Bredesen, M.D., is a professor of neurology at the Easton Laboratories for Neurodegenerative Disease Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr. Bredesen's laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer's disease and other neurodegenerative conditions. He has collaborated on the publicatio...more
This podcast is a spectacular round two podcast with Dr. Valter Longo. Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy. Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therap...more
Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona. Dr. Raison’s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the...more
Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF. Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to many of you, ketog...more
This is a nearly 2-hour round 2 episode with none other than Dr. Satchin Panda of the Salk Institute! At nearly two hours of dialog, this episode touches on a lot of material but has a special focus on practical implementation of time-restricted eating. Put another way, I kept a list of a lot of questions that seem to keep coming up and present them directly to Satchin. We talk about dealing with shift work, black coffee when fasting, and some of the distinctions between Satchin's approach to ti...more
Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy. He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death. This episode is decidedly focused...more
This podcast features Jari Laukkanen, M.D., Ph.D., a cardiologist and scientist at the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. The results? Massive reductions in mortality and memory disease in a dose-response fashion at 20-year follow-up. In this almost 25-minute episode, we talk about... 00:00...more
Dr. Judith Campisi is a professor of biogerentology at the Buck Institute for Research on Aging and a co-editor in chief of the Aging Journal. As an expert on cellular senescence, the discussion involves a lot of talk about aging and cancer, where senescence plays a very important fundamental role. What are some of the strategies we might use in the future to prevent senescent cells? What causes them in the first place? In this 1-hour long conversation, we discuss a great number of very interes...more
Dr. Gordon Lithgow of the Buck Institute for Research on Aging tells us about worms! Well, more accurately, his lab does research on nematodes, particularly an animal known as C. elegans. This unassuming scientific model has a lot of important advantages for science: they can be frozen and subsequently thawed and retain viability, they are extremely well understood down to the precise number of cells in their body and the wiring of their nervous system, known as the connectome. Additionally, the...more
If you're anything like me, having the facts straight can sometimes help you to push through the tough part of building new habits or breaking old bad ones. This podcast talks about the realities about what the science says surrounding the consumption of refined sugar. Some of the facts may surprise you! We talk about the relationship of consumption of refined sugar with... mortality and aging brain function, memory, and neuroinflammation the development of cancer and expression of oncogenes se...more
Today we try to answer or at least explore a big question in the world of health: does saturated fat cause heart disease? This is not an unreasonable concern given the fact that there have been several associative studies that have found a link between saturated fat and heart disease, which is, no doubt, a fat that we find abundantly in the typical American diet since it is richly found in staples like fatty beef, pork, butter, cheese, and other dairy products. And if you're in the United States...more
Does meat consumption cause cancer? Or, put another way… does avoiding meat help prevent cancer? If you aren't already savvy to the topic, this may sound more absurd than it should. Here's why: there have been many, many, many correlative studies that have found that higher meat consumption is associated with a significantly higher risk of cancer and cancer mortality. To try to answer this question we end up going deep into discussing plausible mechanisms that might help explain this phenomenon ...more
The World Health Organization estimates that more than 350 million individuals of all ages have depression and approximately one-third of all patients with depression fail to respond to conventional antidepressant therapies like SSRI’s. The good news is that today, perhaps more than ever, good science is starting to illuminate some of the underlying biological mechanisms surrounding the development of depression. This new understanding may soon help the clinical world develop new approaches to t...more
Dr. Roland R. Griffiths is a clinical pharmacologist at Johns Hopkins and has been researching mood-altering compounds for over 40 years. As an unusually prolific scientist, having published over 360-times, he's also responsible for having started the psilocybin research program at Johns Hopkins nearly 2 decades ago. In this 1-hour and 15-minute podcast, we discuss… 00:01:03 - the broader story of Dr. Griffiths 40 years of mood-altering drug research, including what got him started and how taki...more
Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University. Much of this conversation, as you might expect given Dr. Fahey's pedigree as a research scientist, is focused on isothiocyanates and, indeed, sulforaphane! While we covered quite a lot on this very topic (isothiocyanates) via my solo podcast a few weeks ago, this covers everything that may have been overlooked.... and, indeed, so much more! Sk...more
This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway. The most potent naturally-occurring inducer of this pathway, a plant compound known as sulforaphane, may be one of the most potent health-enhancing compounds at our disposal and yet... no one is keeping it out of your hands! No $1,000 per pill markup is keeping it out of your hands -- it’s available to anyone willing to take the little bit of time it takes each w...more
This episode of the FoundMyFitness podcast features Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California. Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases. In this podcast, Valter and I discuss... The effects of prolonged fasting, which r...more
Today's episode features Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. If you enjoyed my last episode with Dr. Satchin Panda, I have good news! This will also be a great episode for you, since we talk about some similar ideas, but focus more on the human side of things, especially when it comes to t...more
Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss... The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. T...more
Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. In this episode, coming at the tail end of a rather extreme 23-day water fast for Ray, we discuss, perhaps unsurprisingly, some of the benefits that are associated with fasting! Ray talks about shifting one's perspective from looking at nutrition only through the lens of meeting day-to-day nutritional needs, a...more
This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all around expert on ketosis. In this podcast we discuss... * Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects. * His work ...more
This podcast is with Dr. Peter Attia. Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance. You may have first heard about Dr. Attia from his two interviews that have been on the Tim Ferriss show, or from any number of popular presentations he's given that were filmed and put online. In addition to being a medical doctor, Dr. Attia has done research on the role of regul...more
This podcast has a 20-page report associated with it! Get it now at foundmyfitness.com/cryotherapy. Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli. Rhonda discusses how cold expo...more
This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes), as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii. The race is divided into three stages ...more
In this episode, Dr. Rhonda Patrick chats with Dr. Darya and Kevin Rose. They chat about Darya's fascinating experience on a 10-day silent meditation retreat where she spent around 7 hours a day doing seated meditation, intermingled with another 6 hours a day of walking meditation. They discuss the biological significance of mindfulness while eating, unlocking the mysteries of blood glucose by actually testing your response to foods, or, in Kevin's case, alcoholic beverages. Kevin talks about hi...more
Dr. Rhonda Patrick interviews Dr. Pierre Capel, professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy. Pierre also works with Wim Hof, otherwise known as the iceman (guest on the last podcast) who is especially well-known for some of his amazing physical feats, like staying in a tub with direct contact to ice for over an hour and fifty three minutes. Pierre explains s...more
Dr. Rhonda Patrick interviews Wim Hof also known as the "Iceman." Wim holds the world record for the longest ice bath (1 hour and 53 minutes and 12 seconds), just to name one of his many impressive feats. Dr. Patrick and Wim talk a bit about Wim's back story that culminated in him trying out cold water immersion, the relatively recent 2014 scientific publication of the “Wim Hof Method” which includes cold exposure during training, exposure to bacterial endotoxin, Wim's breathing techniques, and ...more
In this audio recorded Oct. 3rd, 2015, Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). Discussion includes how micronutrient inadequacies are very prevalent, and how her mentor, Dr. Bruce Ames, found that the body does a strategic rationing so that those proteins and enzymes in the body which are essential for short-term survival get their share of vitamins and minerals at the expense of other proteins ...more
In this podcast I discuss some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. I talk about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging and biological aging in general. Get the free report: foundmyfitness.com/meditation-report
In this episode Rhonda talks about how heat stress from using the sauna makes the body more resilient to the stresses of aging, possible reasons why one study associated sauna use with up to a 40% lower all-cause mortality as well as a 50% lower cardiovascular disease related mortality, how it enhances athletic endurance, staves off muscle atrophy, improves regrowth of muscle after disuse, and some of the profound effects on the brain, including the growth of new brain cells, improvement in focu...more
Dr. Justin Sonnenburg is an associate professor of microbiology and immunology at Stanford and Dr. Erica Sonnenburg is a senior research scientist in the Sonnenburg lab where they research many aspects the interaction between diet with the 100 trillion or so bacteria in the gut (specifically the colon) and how this impacts the health of the host (which in this case is a laboratory research mouse). In this episode we discuss the pivotal role fiber plays in fueling good bacteria in the gut to prod...more
Dr. Ronald Krauss, M.D. is the director of atherosclerosis research at Children’s Hospital Oakland Research Institute, Adjunct Professor at UCSF and UC Berkeley. Dr. Krauss is really one of the pioneering scientists that changed the way we all think about cholesterol and saturated fat. He developed an assay that allows the quantification of low density lipoprotein particle size and concentration (known to the wider world as LDL cholesterol) based on a technique which determines the size of the p...more
Meet some of the CHORI bar team: Dr. Bruce Ames, Dr. Joyce McCann, and Dr. Mark Shigenaga. On this podcast we talk about the different types of HDL and LDL cholesterol and what they do in the body. We discuss a low-calorie, micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that Bruce and I briefly touched on in a previous conversation, how each of the components of the bar from the vitamins and minerals to the fiber and polyphenols are all really important but have sepa...more
Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS research foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. In this episode Rhonda and Aubrey discuss the types of damage that cause aging, how aging results in a decrease in the capacity to repair damage, what role epigenetics play in aging, how people age at different rates, chronic inflammation as a driver of aging, factors that are in young blo...more
Dr. Rhonda Patrick answers some of the most popular questions regarding vitamin D including: - How she decides how much vitamin D to supplement with - Can you get too much vitamin D - Is there a difference in vitamin D made from the sun versus a supplement - What form of vitamin D is more bioavailable or absorbed better.
Dan Pardi is a Ph.D candidate that researches sleep neurobiology at Stanford and University of Leiden. He is also co-founder of Dan’s Plan, an online wellness and technology company. In this podcast Rhonda and Dan discuss what the determinants of good sleep are including duration, timing and intensity,the major causes of less sleep in our society, the consequences of sleep loss including decreased purging of toxic substances from the brain, damage to neurons that signal to the brain to stay awa...more
Tim Ferriss, notorious self-experimenter, three-time New York Times bestselling author, an angel investor, startup advisor, and much, much, much more. Full audio transcript available at: http://wwww.foundmyfitness.com/timtranscript
Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX. In this podcast Rhonda and Jim discuss the quantified self movement and the importance of measuring biomarkers more than once, the gut's role in cholesterol and serotonin in the gut versus in the brain, about the role of exercise in preventing neuroinflammation and the effects of overtraining on sex hormones, a bit about the psychology of constructing a new, non-gender segregated, team spectator sport and bringing ...more
Dr. Rhonda Patrick speaks with Dr. Bruce Ames, about a micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that was developed in the Ames laboratory. The bar was formulated to be moderate in calories (107 kcal/≈25 g bar), but nutrient dense, with a polyphenolic-rich matrix of fruit, walnuts, and non-alkali-processed dark chocolate, supplemental vitamins, minerals, docosahexaenoic acid (DHA), a blend of insoluble and soluble fibers, protein, and glutamine. Most vitamins an...more
In this video Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.
This podcast breaks down, point-by-point what gene polymorphisms you might look at, and how they relate to very specific micronutrients. A few examples of genes with common polymorphism discussed are MTHFR and folate, NBPF3 and vitamin B6, FUT2 and vitamin B12, BCMO1 and beta-carotene, FADS2 and omega-3 fatty acids, CYP2R1 and vitamin D, PEMT and choline as well as APOE4 and FOXO3. NOTE: this video is for informational purposes only! Please consult with your physician before making chan...more
In this podcast Dr. Rhonda Patrick interviews Dr. Bruce Ames about his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution. When cells run out of a vitamin or mineral, that scarce micronutrient is allotted to proteins (in the body) essential for short-term survival. Proteins needed for long-term health, including those that protect DNA, lose out and become disabled and lead to diseases of ag...more
Dr. Rhonda Patrick sheds some light on the recent misleading headline stating that cancer is mostly due to bad luck. Of course, there is a bad luck component to cancer -- but there's also a very, very large environmental and lifestyle component. She addresses the many misleading ideas that accompanied this study, explains what the study actually showed, and also discusses an important role for magnesium in preventing random mutations. The title of the study that spurred this particular video is ...more
In this interview Dr. Rhonda Patrick talks to Dr. Frans Kuypers about his lab’s discovery on how the human placenta is a rich source of pluripotent stem cells and yet the placenta is thrown away after delivery. They discuss how his lab has shown that the stem cells from the placenta can be transformed into neuron-like cells, fat cells, bone cells, endothelial cells (relevant for lung and blood vessels), and liver cells. His lab also developed a technique for harvesting 5 to 7 times more hematopo...more
In this podcast I interview Dr. George A Brooks, an expert in exercise physiology and lactate metabolism. Lactate, a once demonized molecule thought to form lactic acid and become a dead-end toxic metabolite, has been vindicated by the work of Dr. Brooks, his colleagues, and others. Lactate has been shown not be the cause of muscle fatigue, but to actually be a source of energy itself, even being metabolized greedily with a greater degree of preference than many other more well-known sources of ...more
Dr. Rhonda Patrick discusses the differences between krill oil and fish oil in terms of bioavailability and transport into different cells. She explains how DHA and EPA from fish oil in ethyl ester form (molecularly distilled) is the least bioavailable due. She also explains why omega-3 fatty acids in phospholipid from from krill oil are more bioavailable than EPA and DHA in triglyceride form from fish oil. She talks about the differences in transport of DHA into the brain and why krill oil has ...more
Dr. Rhonda Patrick explains what antioxidants are, why they are important, and how they prevent DNA damage, a well-known cancer initiator, in order to minimize damage to DNA. However, in the context of someone that already has cancer, DNA damage can activate genes that kill cancer cells. Dr. Patrick also reveals there are two major forms of vitamin E (alpha and gamma tocopherol) that have separate functions. Taking mega doses (i.e. 400 IU/day) of alpha tocopherol actually DEPLETES gamma tocopher...more
In this video Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles. She identified vitamins/minerals and other compounds present in vegetables/fruits that are essential for mitochondrial health, which is critical for brain function.
Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" causes adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and muscle mass (by boosting levels of heat shock proteins and growth hormone). She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.
A talk originally delivered at SF Nerd Nite that discusses the interesting world of epigenetics.Dr. Rhonda Patrick talks about how to hack your genes through diet and lifestyle. Transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation revering neurodegenerative disease, exercise increases neurogenesis, and vitamin D controls aging.
In this podcast we discuss and critically analyze a recent headline-grabbing editorial that was published in the Annals of Internal Medicine that reviewed three studies on the topic of multivitamins and chronic disease prevention. We analyze the important shortcomings of the studies and talk about the mechanism.
There is a trade off when it comes to growth hormone and IGF-1. Growth hormone and IGF-1 enhance muscle and cognitive performance but this comes at a cost: longevity.
Dr. Patrick talks about how vitamin D regulates the aging process. In this video you will learn important factors that affect vitamin production from your skin, what the optimal levels of serum vitamin D are, and how appropriate vitamin D levels ("the sweet spot") prevents telomeres from shortening.
Over 56% of US population is deficient in magnesium due to three factors: decreased consumption of chlorophyll containing vegetables, decreased absorption, and increased excretion.
Dr. Patrick describes how magnesium, an essential mineral that 56% of the US population is deficient in, can help you maximize your mitochondria to increase oxidative capacity and enhance exercise performance.
Part 1 of 2 of the FoundMyFitness "Understanding Cancer" video series. Dr. Patrick explains the mechanism that cause cancer and how your diet can play a role. She discusses how magnesium is an essential mineral required to repair damaged DNA in order to prevent cancer-causing mutations
Part 2 of 2 the FoundMyFitness "Understanding Cancer" video series. Dr. Patrick discusses how cruciferious vegetables contain compounds that activate tumor suppressor genes that kill cancer cells.